Nat Genet. Wild-type mice that were cohoused with inflammasome-deficient mice also exhibited worsened NASH. Control mice that received the gut microbiota from HFD mice demonstrated more severe liver fibrosis after BDL than HFD mice that were transplanted with gut microbiota from chow-fed mice.
J Appl Toxicol 34 6: The available evidences show that bacterial proliferation and increased intestinal permeability contribute to the development of NAFLD through hepatotoxic bioproducts, modulation of bile acid metabolism, and chronic metabolic endotoxemia with involvement of bacterial lipopolysaccharide, CD14, TLR4 and Kuppfer cell-dependent mechanisms.
PLoS Pathog 11 1: The inflammasomes.
Many recent studies have reported that changes in the composition of the gut microbiota contribute to control of weight gain, development of obesity and related metabolic disorders [ 49 - 11 ]. Am J Clin Nutr 87 3: Sookoian S, Pirola CJ.
Eur J Gastroenterol Hepatol. Therefore, the gut microbiota might contribute to obesity through increases in the harvest of energy from diet, gut permeability, and fat deposition in adipose tissue and the liver.
Microorganisms are introduced into the human gut after birth, and the microbial composition of the microbiota varies with delivery methods, feeding i. Given that the gut and liver are connected by the portal venous system, it makes the liver more vulnerable to translocation of bacteria, bacterial products, endotoxins or secreted cytokines.
Gut microbiota composition and function, especially bile acid physiology, are affected throughout the spectrum of alcohol use disorder, and these changes can improve after alcohol cessation in patients without alcoholic liver disease. Int J Obesity 34 J Exp Med.
Widhalm K, Ghods E Nonalcoholic fatty liver disease: According to Samuel et al. HFD-related increases in liver fibrosis were associated with gut dysbiosis, especially an increase in Proteobacteria. Expert Opin Ther Targets.
Liver cancer A recent study established a link between the gut microbiota and NAFLD-related hepatocellular carcinoma [ 21 ]. J Hepatol 45 4: Loomba R, Sanyal AJ.Nonalcoholic fatty liver disease (NAFLD) is the liver manifestation of the metabolic syndrome and thus evolves in the same context as these metabolic diseases.
It is therefore not surprising that recent literature emphasizes a potential role for gut dysbiosis in the pathophysiology of NAFLD. microbiota and thereby modulate its effects on human pathophysiology. This review provides an overview of the relationship between the gut microbiota and liver diseases in orderCited by: 2.
Gut Microbiota Proﬁling of Pediatric Nonalcoholic Fatty Liver Disease and Obese Patients Unveiled by an Integrated Meta-omics-Based Approach Federica Del Chierico,1* Valerio Nobili,2,3* Pamela Vernocchi, 1Alessandra Russo, Cristiano De Stefanis, 3Daniela Gnani,Cited by: Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease in developed countries.
Obesity is the most important risk factor for metabolic syndrome and NAFLD. Changes in gut microbiota due to supplemented fatty acids in diet-induced obese mice - Volume Issue 4 - Jorge R.
Mujico, Gyselle C. Baccan, Alina Gheorghe, Ligia E.
Díaz, Ascensión MarcosCited by: The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota.
Hepatology. ;– Hepatology. ;–Cited by: 3.